个人简介

2023.09-至今  湖北理工学院医学院，讲师

荣誉：湖北理工学院新进教师教学能力大赛三等奖

代表性论文

1.A Protein Vaccine with   Alum/c-GAMP/Poly(I:C) Rapidly Boosts Robust Immunity against SARS-CoV-2 and   Variants of Concern. Chem. Commun. 2022, 58, 3925–3928.

2.Adjuvant-Protein Conjugate Vaccine with   Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and   Variants of Concern. ACS Infect. Dis. 2022, 8, 1367–1375.

3.Adjuvant-Free COVID-19 Vaccine with   Glycoprotein Antigen Oxidized by Periodate Rapidly Elicits Potent Immune   Responses. ACS Chem. Biol. 2023, 18, 915–923.

4.Multifunctional Lipidated Protein Carrier   with a Built-In Adjuvant as a Universal Vaccine Platform Potently Elevates   Immunogenicity of Weak Antigens. J. Med. Chem. 2024, 67, 8, 6822–6838.

5.Novel Sialoglycan Linkage for Constructing   Adjuvant-Protein Conjugate as Potent Vaccine for COVID-19. J. Control.   Release 2023, 355, 238–247.

6.pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O   Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to   Induce Potent and Broad-Spectrum Immunity. ACS Appl. Mater. Interfaces 2023,   15, 8914–8926.

7.RBD Conjugate Vaccine with a Built-in   TLR1/2 Agonist Is Highly Immunogenic against SARS-CoV-2 and Variants of   Concern. Chem. Commun. 2022, 58, 2120–2123.

代表性科研项目

1.基于新型佐剂技术的新冠病毒疫苗，国家自然科学基金面上项目，2022-01-01至2025-12-31，参与。

2.化学合成均一结构N-连接糖蛋白的方法和应用，国家自然科学基金面上项目，2018-01-01至2021-12-31，参与。

研究方向

  免疫佐剂分子的设计合成

  亚单位疫苗的免疫研究

团队名称及成员

名称：用于肿瘤联合免疫治疗的靶向HDAC的多肽药物&脂质体糖肽疫苗的构建和抗肿瘤活性研究

成员：杜晶晶、程斌斌、赵长虹、张如岩、林静等